While watching some of his most humiliating clips online, an email pops up from ACME. Wile E. Coyote then buys an ACME Giant Spray and makes himself bigger to outsmart the Road Runner. He tries chasing him but loses him. He makes himself bigger and Road Runner runs all over his body with Wile E. trying to smack him, but ends up whacking himself. Then the giant spray wears out and he goes back to his normal size and falls off a cliff. Then the normal size wears off and Wile E. gets so big he ends up on top of the earth.
The title is a parody of Fee Fi Fo Fum, the first line of a historical quatrain as heard in the English fairy tale "Jack and the Beanstalk".